Diphenidol Has No Actual Broad Antiemetic Activity in Dogs and Ferrets

Journal of Pharmacological Sciences

Hisashi Yamakuni¹  Yasue Maeda¹  Masahiko Matsuo¹  Katsunori Imazumi¹  Hiroe Nakayama¹  Seitaro Mutoh¹  Aya Nakayama¹ 

[1] Department of Urology, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

关键词: cisplatin;    copper sulfate;    apomorphine;    loperamide;    pica;   

DOI  :  10.1254/jphs.FPJ04035X

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(22)Cited-By(4)Previous studies showed that diphenidol was effective on emetogens-induced pica, eating of non-nutritive substances, in rats, a model analogous to emesis in other species. We evaluated the actual antiemetic activity of diphenidol against four emetic stimuli in the dog and ferret, animals that possess an emetic reflex. In dogs, emetic responses to apomorphine were significantly prevented by diphenidol (3.2 mg/kg, i.v.), whereas diphenidol (3.2 mg/kg, i.v. × 2) showed a weak inhibition to the vomiting evoked by cisplatin. In ferrets, diphenidol (10 mg/kg, i.p.) exhibited a weak antiemetic activity on the emesis induced by copper sulfate and had no activity on emesis by loperamide. On the other hand, CP-122,721, a NK1-receptor antagonist, significantly reduced the emetic episodes to all four stimuli. These results suggest that the prediction of antiemetic activity of compounds in animals lacking an emetic reflex does not always correspond with actual antiemetic activity.

【 授权许可】

Unknown