Serum Concentration of the Pyridinoline Cross-Linked Carboxyterminal Telopeptide of Type I Collagen (ICTP) Is a Useful Indicator of Decline and Recovery of Bone Mineral Density in lumbar Spine: Analysis in Japanese Postmenopausal Women With or Without Hormone Replacement

Endocrine Journal

SUMIO IIJIMA²  TAKEHIKO YASUMIZU¹  KAZUHIKO HOSHI¹  AKIO ASAKA² 

[1] Department of Obstetrics and Gynecology, Yamanashi Medical University;Department of Health Science, Yamanashi Medical University

关键词: Bone mineral density;    Lumbar spine;    Carboxyterminal telopeptide of type I collagen (ICTP);    Carboxyterminal telopeptide of type I procollagen (PICP);    Postmenopausal woman;   

DOI  :  10.1507/endocrj.45.45

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(25)Cited-By(14)To reassess the clinical utility of serum pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), a promising but controversial indicator of bone resorption, we evaluated its performance as a biochemical marker in a 6-month study of a strictly selected population of 76 Japanesepostmenopausal and healthy women, 33 recipients of hormone replacement therapy and 43 non-recipients. We measured bone mineral density (BMD) of the lumbar spine (L2-L4), and serum ICTP, carboxyterminal propeptide of type I procollagen (PICP) and other conventional serum biochemicalmarkers, e.g. bone gla protein (BGP), alkaline phosphatase, calcium and phosphate at the entry and 6 months later. We calculated the percent change between the baseline and 6-month values (Δ%) in lumbar BMD and the biochemical markers, individually, and compared the degree of correlationsbetween Δ% in BMD and that in the biochemical markers. Δ% in ICTP and Δ% in BGP correlated with Δ% in BMD negatively and ignificantly. Especially Δ% in ICTP correlated with that in BMD to a high degree (P<0.0001). No significant correlation was observed in other biochemical markers. We concluded that serum ICTP is a sensitive and useful bone resorption marker in the postmenopausal population, which strongly correlates with the change in BMD.

【 授权许可】

Unknown