Correlation between, Clinical, Biochemical, Color Doppler Ultrasound Thyroid Parameters, and CXCL-10 in Autoimmune Thyroid Diseases

Endocrine Journal

Giovanni CORONA¹  Barbara CONFORTI¹  Nadia CREMONINI³  Mario SERIO¹  Andrea BONAMANO¹  Mario ROTONDI⁴  Luisa PETRONE¹  Carlo BIAGINI²  Gianni FORTI¹ 

[1] Endocrinology Unit, Department of Clinical Physiopathology, University of Florence;Radiology Unit, Misericordia Institute;Endocrinology Unit, Maggiore-Bellaria Hospital;Unit of Internal Medicine and Endocrinology, Fondazione S. Maugeri I.R.C.C.S., University of Pavia

关键词: Thyroid color doppler ultrasound;    Autoimmune thyroid diseases;    Chemokines;    CXCL-10;   

DOI  :  10.1507/endocrj.K07E-052

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(29)Cited-By(9)Objective: the aim of present study is to determine possible contributions of INF-γ inducible chemochine CXCL-10 in the thyroid color doppler ultrasound (CDU) parameters typical of autoimmune disorders. Methods: we studied a consecutive series of 25 patients with autoimmune thyroid disease and 10 healthy control subjects. All subjects underwent a thyroid CDU examination by the same investigator, who was unaware of the laboratory values at the time of the examination. Moreover, all subjects underwent a clinical evaluation, CXCL-10 and thyroid hormonal assessment. Results: CXCL-10 levels were significantly higher in patients with autoimmune diseases and as well as in subjects with an increased thyroid vascularization at CDU. Moreover, CXCL-10 levels were significantly (p<0.05) correlated with inferior thyroid arteria peak systolic velocity (ITA-PSV; r = 0.376) and with thyroid volume even after adjustment for confounding factors. No difference was observed between vascular thyroid pattern at CDU and thyroid circulating hormones while, ITA-PSV was significantly associated with TSH (Adj. r = -0.373; p<0.05). Conclusions: our data seem to suggest that CXCL-10 could play an important role in the intra-thyroid angiogenesis modulation, explaining, at least partiality, CDU findings typical of thyroid autoimmune diseases. Moreover we confirmed previous reports considering ITA-PSV as the best CDU parameters in the differential diagnosis of thyroid autoimmune disorders.

【 授权许可】

Unknown