Follicular thyroid carcinoma with skull metastases

Endocrine Journal

Francesca Di Gennaro¹  Nunzia Simona Losito³  Orlando Catalano⁴  Fabio Sandomenico⁴  Franco Fulciniti³  Giuseppe Catapano²  Sergio Venanzio Setola⁴  Maria Grazia Chiofalo⁵  Luciano Pezzullo⁵ 

[1] Department of Nuclear Medicine, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, via Mariano Semmola, 80131 Naples, Italy;Department of Neurosurgery, AORN G. Rummo, via Dell’Angelo I, 82100, Benevento, Italy;Department of Pathology, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, via Mariano Semmola, 80131 Naples, Italy;Department of Radiology, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, via Mariano Semmola, 80131 Naples, Italy;Thyroid and Parathyroid Surgery Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, via Mariano Semmola, 80131 Naples, Italy

关键词: Follicular thyroid cancer;    Skull metastases;    Bone metastases;   

DOI  :  10.1507/endocrj.EJ14-0553

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(19)Thyroid carcinoma with distant metastases at initial presentation, is uncommon.Skull metastases occur very rarely, with a reported incidence of 2.5-5.8%.Here we report two cases of follicular thyroid cancer with skull involvement, and describe the diagnostic and therapeutic approach to metastatic thyroid cancer.We present the cases of a 70-year-old female and a 74-year-old female who presented with painless, large slow-growing masses of the skull.The patients underwent surgical excision of the skull masses, which were histologically diagnosed as metastatic follicular thyroid cancer, and total thyroidectomy, which confirmed the diagnosis of follicular thyroid carcinoma.They were treated with radioiodine and suppressive levothyroxine, which achieved local control of the disease.Management of metastatic thyroid cancer, requires a multidisciplinary approach and multimodality treatment.Distant metastases should be surgically removed whenever possible.Initial aggressive treatment is crucial in the management of metastatic thyroid carcinoma, providing the best chance to prolong patient survival.

【 授权许可】

Unknown