Matrix metalloproteinases and their considerations in Dentistry from the field of computational chemistry

Revista Cubana de Estomatología

Méndez Cuadro, Darío¹  Velásquez, Margarita Rosa¹  Orozco Páez, Jennifer¹  Díaz Caballero, Antonio¹  Martínez Serrano, Emiliano¹ 

[1] Universidad de Cartagena, Colombia

关键词: matrix metalloproteinases;    tissue inhibitors of metalloproteinases;    computational molecular biology;   

DOI  :  

学科分类：基础医学

来源: SciELO

【 摘 要 】

Matrix metalloproteinases are a family of zinc-dependent proteases responsible for the remodeling the protein components of extracellular matrix of all tissues; its catalytic activity is controlled by tissue inhibitors of matrix metalloproteinases. At pathological conditions the balance between MMPs regarding these endogenous inhibitors is lost, this imbalance is evident in oral diseases including dental caries, gingivitis, periodontitis, among others, hence the possibility of achieving selective inhibition of activity of these enzymes with synthetic inhibitors is a promising approach in the treatment of various diseases of the oral cavity. A literature review aimed at analyzing the role of matrix metalloproteinases in the development of oral diseases and identify the contribution made by the computational analysis of these enzymes in the field of dentistry is presented below. To this end a search of the literature available was conducted in databases such as Pubmed, Sience Direct, Ovid, and Ebsco Host using

【 授权许可】

Unknown