Nonsuppurative Myocarditis Caused by Porcine Circovirus Type 2 in a Weak-Born Piglet

Journal of Veterinary Medical Science

Hiroaki NAKAJIMA³  Osamu MIKAMI⁴  Masaaki YOSHII¹  Yasuyuki NAKAJIMA⁴  Kenji KAWASHIMA² 

[1] Environmental Virology Section, Department of Infectious Diseases, National Institute of Animal Health;Environmental Hygiene Section, Shichinohe Research Unit, National Institute of Animal Health;Yamagata Central Livestock Hygiene Service Center;Toxico-Pathology Section, Department of Safety Research, National Institute of Animal Health

关键词: myocarditis;    porcine circovirus type 2;    reproductive failure;   

DOI  :  10.1292/jvms.67.735

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(23)Cited-By(4)Reproductive failure associated with porcine circovirus type 2 (PCV2) was observed in a farm, and a weak-born 8-day-old piglet was examined pathologically. Focal to locally extensive lesions, including infiltration of macrophages and lymphocytes, fibrosis and degeneration of the myocardium were observed in the heart. PCV2 antigens and nucleic acids were detected in degenerated cardiomyocytes and macrophages infiltrating the heart by immunohistochemical staining and in situ hybridization. Depletion of lymphocytes with occasional infiltration of multinucleated giant cells was seen in the lymphoid organs and PCV2 antigens were demonstrated in histiocytic cells. Crystalline arrays of viral particles were observed in infiltrated macrophages in the heart and, rarely, in cardiomyocytes by electron microscopy. Although myocarditis is a common finding in aborted or stillborn piglets in reproductive failure due to PCV2, it was also observed in the 8-day-old piglet with PCV2 association.

【 授权许可】

Unknown