Towards predictive resistance models for agrochemicals by combining chemical and protein similarity via proteochemometric modelling

Journal of Chemical Biology

John P. Overington¹  Andreas Bender¹  Gerard J. P. van Westen¹ 

[1]European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD United Kingdom

关键词: Polypharmacology;    Cheminformatics;    Machine learning;    Resistance;   

DOI  :  10.1007/s12154-014-0112-2

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Resistance to pesticides is an increasing problem in agriculture. Despite practices such as phased use and cycling of ‘orthogonally resistant’ agents, resistance remains a major risk to national and global food security. To combat this problem, there is a need for both new approaches for pesticide design, as well as for novel chemical entities themselves. As summarized in this opinion article, a technique termed ‘proteochemometric modelling’ (PCM), from the field of chemoinformatics, could aid in the quantification and prediction of resistance that acts via point mutations in the target proteins of an agent. The technique combines information from both the chemical and biological domain to generate bioactivity models across large numbers of ligands as well as protein targets. PCM has previously been validated in prospective, experimental work in the medicinal chemistry area, and it draws on the growing amount of bioactivity information available in the public domain. Here, two potential applications of proteochemometric modelling to agrochemical data are described, based on previously published examples from the medicinal chemistry literature.

【 授权许可】

Unknown