Determination of reference intervals of glycated albumin and hemoglobin A1c in healthy pregnant Japanese women and analysis of their time courses and influencing factors during pregnancy

Endocrine Journal

Yuji Hiramatsu⁴  Masao Nakabayashi³  Yasue Omori¹  Ikki Shimizu² 

[1] Diabetes Center, Ebina General Hospital, Kanagawa 243-0433, Japan;Department of diabetology, The Sakakibara Heart Institute of Okayama, Okayama 700-0823, Japan;Department of Gynecology and Obstetrics, Aiiku Maternal & Child Health Center, Aiiku Hospital, Tokyo 106-8580, Japan;Department of Obstetrics & Gynecology, Okayama University Graduate School, Okayama 700-8558, Japan

关键词: Glycated albumin (GA);    Glycated hemoglobin (HbA1c);    Healthy pregnant women;    Reference intervals;    Diabetes mellitus;   

DOI  :  10.1507/endocrj.K10E-410

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(25)Cited-By(15)Glycemic control is an important issue in gestational diabetes mellitus (GDM) and in diabetic pregnant women.We determined the reference intervals of glycated albumin (GA) and hemoglobin A1c (HbA1c) as glycemic control markers in healthy Japanese pregnant women and analyzed their time courses and factors that influence these variables during pregnancy.676 women were screened for the present study.After the exclusion of non-pregnant and puerperal women, 574 women were studied to determine the reference intervals.HbA1c, GA, casual plasma glucose, urinary glucose, urinary protein, and body mass index (BMI) (non-pregnancy) were measured.HbA1c levels significantly decreased in the second trimester of pregnancy and increased in the third trimester, while GA levels significantly decreased towards the third trimester.Casual plasma glucose levels decreased in the first trimester and subsequently remained constant.The reference intervals of GA and HbA1c in the healthy pregnant women were 11.5-15.7% and 4.5-5.7%, respectively. GA levels were lower (ppp2), and HbA1c levels were higher (p<0.01) than those of the control group.On the basis of the results of this multicenter study, the reference intervals of GA and HbA1c in healthy Japanese pregnant women were determined.Strict glycemic control is essential to reduce perinatal complications.GA appears to be a useful marker for pregnant women, since it can be measured easily and changes rapidly and markedly.

【 授权许可】

Unknown