Lifestyle modification increases serum testosterone level and decrease central blood pressure in overweight and obese men

Endocrine Journal

Seiji Maeda²  Asako Zempo-Miyaki¹  Hiroshi Kumagai³  Kiyoji Tanaka²  Takehiko Tsujimoto²  Toru Yoshikawa³ 

[1] Faculty of Sports and Health Sciences, University of Ryutsu keizai, Ryugasaki, Japan;Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan;Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

关键词: Testosterone;    Obesity;    Central blood pressure;    Lifestyle modification;   

DOI  :  10.1507/endocrj.EJ14-0555

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(33)Cited-By(3)Obesity has reached global epidemic proportions and is associated with multiple comorbidities, including cardiovascular disease.A novel predictor of cardiovascular disease is elevated central systolic blood pressure.In fact, lifestyle modifications have been shown to decrease the central systolic blood pressure in overweight and obese men.The mechanism underlying these changes has yet to be fully elucidated.Interestingly, testosterone has been found to have cardioprotective effects.Moreover, serum testosterone levels are lower in obese men than in normal weight men.However, it is still unclear whether testosterone participates in the decrease of central blood pressure in overweight and obese men following lifestyle modifications.So, the purpose of the present study was to investigate the effect of testosterone on central systolic blood pressure in overweight and obese men before and after the 12-week lifestyle modification program.Forty-four overweight and obese men completed a 12-week lifestyle modification program (aerobic exercise training and dietary modifications).For all participants, central systolic blood pressure and serum testosterone levels were measured before and after the program.After the program, central systolic blood pressure was significantly decreased while serum total testosterone levels were significantly increased in overweight and obese men.Moreover, we also found a significant negative relationship between the change in serum testosterone levels and that in central systolic blood pressure.The present study suggests that increased serum testosterone levels likely contribute to a decrease in central blood pressure in overweight and obese men.

【 授权许可】

Unknown