Neurocognitive ability in children with sickle cell disease and its relationship with the hemoglobin value

Revista Cubana de Hematología, Inmunología y Hemoterapia

Menéndez Veitía, Andrea¹  Svarch, Eva¹  Álvarez González, Miguel Ángel²  Machado Almeida, Teresita¹  Martínez Triana, Raúl¹ 

[1] Instituto de Hematología e Inmunología, La Habana, Cuba;Instituto de Neurología y Neurocirugía, La Habana, Cuba

关键词: Sickle cell disease;    neurocognition;    cognitive;    neuropsychological assessment;   

DOI  :  

学科分类：生理学与病理学

来源: SciELO

【 摘 要 】

It is known for decades that there is a cognitive deficit in children with sickle cell disease, and anemia has been regarded as one of the causes. Neuropsychological measures were obtained with the Wechsler Intelligence Scale in 119 patients aged 6 to 18 years, and compared with 42 healthy children of similar age and sex. In 87 cases, we obtained the annual averages of the values of hemoglobin (Hb) collected from medical records at follow-up visits until the time of evaluation. It was observed a decrease in the ratios of full-scale intelligence (ET, p= 0.024), the executive level (EE, p= 0.008) and also information on the subscales (p= 0.004), order figures (p= 0.017) and block design (p= 0.003), with respect to the healthy ones. Differences were observed between the results of patients with genotypes considered as more severe (SS and thalassemia Sb0) with less severe (Sb+ thalassemia SC) in ET (p= 0.033) and EE (p= 0.011). We found a significant relationship between Hb annual average of 4 to 6 years of age with ET (p= 0.023), the verbal scale (p= 0.028), sub scales information (p= 0.010), comprehension (p= 0.024), vocabulary (p= 0.022) and block design (p= 0.011). These results confirm the cognitive deficits in patients with sickle cell disease and relate them to the severity of anemia in preschool ages.

【 授权许可】

CC BY-NC