Effects of DDAVP Administrated Subcutaneously in Dogs with Aspirin-induced Platelet Dysfunction and Hemostatic Impairment due to Chronic Liver Diseases

Journal of Veterinary Medical Science

Atsuhiko HASEGAWA¹  Toshihiro WATARI²  Haruhiko MARUYAMA²  Manabu SAKAI²  Teruhisa MIURA²  Akira TAKEUCHI²  Hiroshi KOIE²  Yoshiki YAMAYA² 

[1] Laboratory of Pathobiology, Department of Veterinary Medicine, Nihon University;Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University

关键词: aspirin-induced platelet dysfunction;    canine;    chronic liver disease;    DDAVP;    hemostasis;   

DOI  :  10.1292/jvms.65.83

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(4)To evaluate the hemostatic effects of desmopressin (DDAVP) in dogs with aspirin-induced platelet dysfunction and hemostatic impairment in chronic liver diseases, 3 μg/kg DDAVP was administrated subcutaneously. In aspirin-induced platelet dysfunction dogs (n=5), prolonged BMBT (buccal mucosal bleeding time) was shortened significantly after DDAVP injection (2.2 ± 1.2 min, P<0.05). In dogs with chronic liver diseases (n=4), activated partial thromboplastin time (APTT) tended to shorten by 0.9 to 3.0 sec, and prolonged BMBT was shortened in two cases for 4.2 and 1.7 min after DDAVP injection. Therefore, the present results indicated that DDAVP shortened the prolonged BMBT in dogs with aspirin-induced platelet dysfunction and chronic liver disease. DDAVP might be helpful in hemostasis under invasive procedures such as biopsy or surgery for dogs with hemostatic impairment.

【 授权许可】

Unknown