Gonadotropin-Releasing Hormone-Induced Elevation of Serum hCG in Choriocarcinoma

Endocrine Journal

NOBUAKI IMAI¹  HIROYUKI ODA¹  YUKI MIYABE¹  MADOKA FURUHASHI¹  YOSHINARI KATSUMATA¹ 

[1] Department of Obstetrics and Gynecology, Handa City Hospital

关键词: Gestational trophoblastic disease;    GnRH;    hCG;    Chemotherapy;   

DOI  :  10.1507/endocrj.45.585

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(24)Cited-By(1)We evaluated the effect of GnRH on the serum hCG level in gestational trophoblastic disease (GTD). Five patients with GTD were studied. Three patients had hydatidiform mole (two complete and one partial mole) and two had choriocarcinoma. Blood samples were collected immediately before and 30, 60min after the 100μg GnRH iv injection, followed by hCG assay. Only one case of choriocarcinoma demonstrated an hCG increase after intravenous administration of GnRH (positive GnRH test). In that case, the hCG level dropped to the normal range after eight cycles of chemotherapy but the GnRH test was still positive, suggesting the existence of viable cancer cells. Since the GnRH test became negative, no increase in hCG has been observed, indicating that the patient achieved complete remission. Although a positive GnRH test is not common in GTD, GnRH test before treatment might be useful to find a positive case where the test can be repeated to determine complete remission and the time when the chemotherapy may be discontinued.

【 授权许可】

Unknown