Colitis Associated with Clostridium difficile in Specific-Pathogen-Free C3H-scid Mice

Journal of Veterinary Medical Science

Akihiro KAWANO¹  Tatsuo HAYAO²  Toshiaki KOKUBO¹  Kaori WATANABE³  Manabu IKEDA¹  Riichirou IRITANI³  Akiko KINOSHITA³  Satoru MATSUSHITA¹ 

[1] Laboratory Animal Development and Research Group, Research Center for Radiation Safety, National Institute of Radiological Sciences;Laboratory Animal Sciences Section, Department of Technical Support and Development, National Institute of Radiological Sciences;Science Service Co.

关键词: C3H-scid mouse;    Clostridium difficile;    colitis;   

DOI  :  10.1292/jvms.69.973

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(18)Cited-By(1)Soft feces and a decreased delivery rate were observed in a specific-pathogen-free (SPF) C3H-scid mouse breeding colony. Grossly, the ceca were shrunken and edematous in the affected mice. Histopathologically, severe edema in the cecal submucosa as well as infiltration of inflammatory cells in the lamina propria and submucosa of the ceca and colon were observed. No pathogenic microorganisms were detected by the routine microbiological tests. By anaerobic bacterial-examination, Clostridium (C.) difficile with toxin A was isolated from the cecal contents of the affected mice. The mice were diagnosed with C. difficile-associated colitis. This case appears to be the first report of natural infection with C. difficile in SPF mice with clinical signs.

【 授权许可】

Unknown