T-type Calcium Channels: Functional Regulation and Implication in Pain Signaling

Journal of Pharmacological Sciences

Atsufumi Kawabata¹  Fumiko Sekiguchi¹ 

[1] Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, Japan

关键词: Cav3.2;    T-type calcium channel;    neuropathy;    visceral pain;    hydrogen sulfide;   

DOI  :  10.1254/jphs.13R05CP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(42)Cited-By(19)Low-voltage-activated T-type Ca2+ channels (T-channels), especially Cav3.2 among the three isoforms (Cav3.1, Cav3.2, and Cav3.3), are now considered to play pivotal roles in processing of pain signals. Cav3.2 T-channels are functionally modulated by extracellular substances such as hydrogen sulfide and ascorbic acid, by intracellular signaling molecules including protein kinases, and by glycosylation. Cav3.2 T-channels are abundantly expressed in both peripheral and central endings of the primary afferent neurons, regulating neuronal excitability and release of excitatory neurotransmitters such as substance P and glutamate, respectively. Functional upregulation of Cav3.2 T-channels is involved in the pathophysiology of inflammatory, neuropathic, and visceral pain. Thus, Cav3.2 T-channels are considered to serve as novel targets for development of drugs for treatment of intractable pain resistant to currently available analgesics.

【 授权许可】

Unknown