Comparison of metabolic profile and adiponectin level with pioglitazone versus voglibose in patients with type-2 diabetes mellitus associated with metabolic syndrome

Endocrine Journal

Fusakazu Jo¹  Hiromi Jo¹  Mitsushige Nishikawa¹  Masayoshi Iwasaki¹  Keisuke Fujitaka¹  Emiko Nomura¹  Toshiji Iwasaka¹  Hajime Otani¹ 

[1] Second Department of Internal Medicine, Kansai Medical University, Moriguchi, Japan

关键词: Type-2 diabetes mellitus;    Metabolic syndrome;    Pioglitazone;    Voglibose;    Adiponectin;   

DOI  :  10.1507/endocrj.K10E-327

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(36)Cited-By(2)Type 2 diabetes mellitus (T2DM) associated with metabolic syndrome (MetS) represents a high risk of cardiovascular disease.We compared the effect of early intervention with pioglitazone versus voglibose on physical and metabolic profiles and serum adiponectin level in patients with T2DM associated with MetS.Sixty patients who were diagnosed for the first time as T2DM associated with MetS were analyzed for insulin sensitivity, lipid profile, serum adiponectin and systemic inflammation.Those patients were randomly assigned to oral pioglitazone group (n = 30) or voglibose group (n = 30) in addition to conventional diet and exercise training.Body mass index and waist circumference did not change in the pioglitazone group, whereas these physical parameters significantly decreased in the voglibose group during a 6-month follow-up period.However, glycosylated hemoglobin, fasting plasma glucose, and HOMA-IR more significantly decreased in the pioglitazone group.The level of serum adiponectin especially high-molecular weight adiponectin markedly increased in the pioglitazone group.Moreover, high sensitive CRP significantly decreased only in the pioglitazone group.These results suggest that voglibose is superior in improving obesity, while pioglitazone is superior in ameliorating insulin sensitivity and increasing serum adiponectin in patients with an early stage of T2DM associated with MetS.

【 授权许可】

Unknown