Thyroid Evaluation in Patients with Primary Hyperparathyroidism

Endocrine Journal

Yutaka KOGA²  Masao TANAKA¹  Ryuichi NISHII²  Toshihiro MASATSUGU²  Shiro NOGUCHI²  Shin WATANABE²  Hiroto YAMASHITA²  Akira OHSHIMA¹  Shinya UCHINO²  Syoji KUROKI¹  Hiroyuki YAMASHITA² 

[1] Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University;Noguchi Thyroid Clinic and Hospital Foundation

关键词: Primary hyperparathyroidism;    Concomitant thyroid disease;    High-resolution ultrasonography;    Ultrasound-guided fine-needle aspiration biopsy;   

DOI  :  10.1507/endocrj.52.177

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(30)Cited-By(11)We evaluated the efficacy of preoperative high-resolution ultrasonography (US) for diagnosing possible concomitant thyroid disease which affects the surgical management in patients with primary hyperparathyroidism (pHPT). One hundred and nine patients with sporadic pHPT underwent US with or without ultrasound-guided fine-needle aspiration biopsy (US-FNAB). Diagnosis of concomitant thyroid nodules by US and US-FNAB were compared with the histopathological findings. Of the 109 patients, 19 (17.4%) had malignant thyroid nodules, 26 (23.9%) had benign thyroid nodules alone, and 12 (11.0%) had diffuse goiter. The sensitivity, specificity, and accuracy of diagnosing 72 thyroid nodules were 91.3%, 91.8%, and 91.7% for US, 57.9%, 94.3%, and 81.5% for US-FNAB, and 95.7%, 91.8%, and 93.1% for combined US and US-FNAB, respectively. True positive/false negative ratio of US-FNAB diagnosis was significantly lower in nodules of 5–9 mm than nodules of 10 mm or more. Four unexpected thyroid cancers existed at a different site in 3 of the 39 patients with palpable thyroid disease. Five thyroid cancers were histopathologically confirmed in 5 (7.1%) of 70 patients without palpable thyroid disease. Eight (88.9%) of the 9 non-palpable thyroid cancers were accurately diagnosed by combined US and US-FNAB. Preoperative US is useful for evaluation of possible concomitant thyroid disease, especially for prediction of malignancy.

【 授权许可】

Unknown