Standardized centile curves and reference intervals of serum insulin-like growth factor-I (IGF-I) levels in a normal Japanese population using the LMS method

Endocrine Journal

Ke-ita Tatsumi²  Toshiaki Tanaka²  Noriyuki Katsumata²  Reiko Horikawa²  Katsuhiko Tachibana²  Akira Teramoto¹  Tsuyoshi Isojima²  Susumu Yokoya²  Akira Shimatsu²  Kazuo Chihara¹  Naomi Hizuka² 

[1] Research Study Group on the Hypothalamo-Pituitary Dysfunction, The Ministry of Health, Labor and Welfare, Tokyo 100-8916, Japan;GH and its Related Factors Study Committee and GH Treatment Study Committee, The Foundation for Growth Science in Japan, Tokyo 113-0033, Japan

关键词: Insulin-like growth factor-I;    Reference intervals;    LMS method;    Japanese population;   

DOI  :  10.1507/endocrj.EJ12-0110

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(37)Cited-By(27)Measurements of insulin-like growth factor-I (IGF-I) are useful not only for diagnosis and management of patients with growth hormone (GH)-related disorders but also for assessing nutritional status.We reported population-based references of serum IGF-I in 1996.However, they did not properly reflect data in the transition period from puberty to maturity.The aim of the present study was to re-establish a set of normative data for IGF-I for the Japanese population.The study included 1,685 healthy Japanese subjects (845 males, 840 females) from 0 to 83 years old.Subjects suffering from diseases that could affect IGF-I levels were excluded.Obese or extremely thin adult subjects were also excluded.IGF-I concentrations were determined by commercially available immunoradiometric assays.The reference intervals were calculated using the LMS method.Median IGF-I levels reached 310 ng/mL in males at the age of 14 years and 349 ng/mL in females at the age of 13 years, falling to 124 ng/mL and 103 ng/mL, respectively, by the age of 70 years.The mean pretreatment IGF-1 SD scores in patients with severe GH deficiency (GHD) obtained from the database of the Foundation for Growth Science and from clinical studies for adult GHD were -2.1±1.6 and -4.9±2.5, respectively.The present study established age- and gender-specific normative IGF-I data for the Japanese population and showed the utility of these references for screening patients with severe GHD.

【 授权许可】

Unknown