A Case of Ambiguous External Genitalia in a Thoroughbred Male Horse with the 63,XO/64,XY Mosaic Karyotype

Journal of Veterinary Medical Science

Harutaka MURASE¹  Teruaki TOZAKI³  Pramod DHAKAL⁴  Keiichi HIROTA³  Fumio SATO¹  Yasuo NAMBO¹  Katsumi ITO⁵  Kazuyoshi TAYA²  Yoshiro ENDO¹ 

[1] Hidaka Training and Research Center, Japan Racing Association, 535–13 Nishicha, Urakawa, Hokkaido 057–0171, Japan;Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183–8509, Japan;Department of Molecular Genetics, Laboratory of Racing Chemistry, 1731–2 Tsurutamachi, Utsunomiya, Tochigi 320–0851, Japan;Department of Clinical Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan;Hidaka Horse Breeders Association, 14 Nobuka, Urakawa, Hokkaido 059–3454, Japan

关键词: ambiguous genitalia;    horse;    mosaic karyotype;   

DOI  :  10.1292/jvms.11-0473

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(22)Cited-By(1)A Thoroughbred colt with ambiguous external genitalia was presented for clinical and histological examinations. The colt had a short penis that faced backward between his hind limbs. The measurements of luteinizing hormone, follicle stimulating hormone, testosterone and ir-inhibin showed a tendency to increase gradually from April. Both the sex-determining region of the Y chromosome and amelogenin gene fragments were detected by the PCR method. A cytogenetic analysis revealed the 63,XO/64,XY mosaic karyotype (ratio 83:17). In autopsy, immature symmetrical subcutaneous testes were found in the inguinal regions. The testes and other accessory sex organs were histologically normal. These results add to our knowledge of chromosomal abnormality and information concerning disorders of sex development in the horse.

【 授权许可】

Unknown