期刊论文详细信息
Journal of Pharmacological Sciences
Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures
Shuji Kaneko1  Maiko Kitaichi1  Hisashi Shirakawa1  Kazuki Nagayasu1  Takayuki Nakagawa1 
[1] Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
关键词: serotonin (5-HT);    3;    4-methylenedioxymethamphetamine (MDMA);    slice culture;   
DOI  :  10.1254/jphs.10075SC
学科分类:药学
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society
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【 摘 要 】

References(15)Cited-By(4)3,4-Methylenedioxymethamphetamine (MDMA) causes serotonin efflux via serotonin transporter. Recently, we have reported that sustained exposure to MDMA induced an augmentation of serotonin release in rat raphe serotonergic slice cultures. Here we investigated the mechanism of augmented serotonin release from the slice cultures. Sustained MDMA exposure had no effect on MDMA-induced serotonin efflux in the synaptosomal fraction, whereas either tetrodotoxin, calcium channel inhibitors, or AMPA-receptor antagonists significantly attenuated the augmented serotonin release. These results suggest that the increase in Ca2+-dependent exocytotic serotonin release is mediated through activation of AMPA receptors and responsible for the sustained MDMA-induced augmentation of serotonin release.

【 授权许可】

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