Secondary Erythrocytosis Associated with Schwannoma in a Dog

Journal of Veterinary Medical Science

Tamiko OHTA¹  Akiko YAMAUCHI¹  Kunio DOI²  Taro OKADA²  Satoru MATSUNAGA¹  Hiroyuki NAKAYAMA²  Nobuo SASAKI¹  Ryohei NISHIMURA¹  Manabu MOCHIZUKI¹ 

[1] Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

关键词: canine;    erythrocytosis;    schwannoma;   

DOI  :  10.1292/jvms.66.1605

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(6)An 11-year-old, spayed female mixed-breed dog showed clinical signs of right forelimb lameness and pain by palpation around the neck. Radiography and computed tomography (CT) revealed an extradural mass at the 6th and 7th cervical vertebrae, which compressed the spinal cord. The mass was surgically removed and histopathologically diagnosed as schwannoma. The dog recovered her normal gait after hemilaminectomy and removal of the mass. Ten months after the surgery, the tumor recurred with absolute erythrocytosis and was surgically removed again. This removal temporarily resolved the erythrocytosis with a decrease in plasma erythropoietin (EPO) concentration. EPO protein was detected immunohistochemically in the tumor cells. Erythrocytosis in this dog may be caused by ectopic EPO produced in the schwannoma tissues.

【 授权许可】

Unknown