期刊论文详细信息
Endocrine Journal
Insulin-Like Growth Factor I Resistance in Peripheral Tissue but not in Liver in Streptozotocin-Induced Diabetic Rats
AKIRA SEKIKAWA1  KEIICHI YAMATANI1  MAKOTO TOMINAGA1  HIDEYUKI EGUCHI1  MASAHIKO IGARASHI1  MAKOTO DAIMON1  HIDEO SASAKI1 
[1] Third Department of Internal Medicine, Yamagata University School of Medicine
关键词: IGF-I;    Streptozotocin;    Insulin resistance;    IGF-I resistance;    Glucose clamp;   
DOI  :  10.1507/endocrj.42.397
学科分类:内分泌与代谢学
来源: Japan Endocrine Society
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【 摘 要 】

References(27)Cited-By(2)The metabolic effect of recombinant human insulin-like growth factor I (IGF-I) was investigated by the glucose clamp technique in normal rats and streptozotocin-induced diabetic rats, a model of insulin-dependent diabetes mellitus (IDDM), and compared with that of insulin. Glucose uptake by peripheral tissues was stimulated by intravenous administration of IGF-I at rates of from 0.369 to 3.690nmol/kg/min in a dose dependent manner, with a potency of 1/52 that of insulin estimated on the basis of the ED50 molar ratio in normal rats. In streptozotocin-induced diabetic rats, the maximum effects of IGF-I and insulin were reduced to 72% and 70% of those in normal rats, respectively, indicating the presence of both IGF-I and insulin resistance. Hepatic glucose output in normal rats was suppressed by IGF-I in a dose dependent manner with a weaker potency of 1/99 that of insulin assessed on the basis of the ED50 values. In streptozotocin-induced diabetic rats, a dose-response curve of the suppressive effect of insulin on hepatic glucose output shifted to the right, indicating the presence of hepatic insulin resistance, but a leftward shifting of the suppressive effect of IGF-I on hepatic glucose output was observed. We concluded that the IGF-I effect on peripheral tissue was decreased but that on the liver was rather increased in streptozotocin-induced diabetic rats, in contrast to the resistance of both peripheral tissues and liver to insulin.

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