A new model applied in prediction of febrile neutropenia in children with acute leukemias

Revista Cubana de Hematología, Inmunología y Hemoterapia

Menéndez Veitía, Andrea³  Núñez Quintana, Aramís¹  Arencibia Núñez, Alberto³  González Otero, Alejandro³  Nordet Carrera, Ileana³  Domínguez Toirac, Marlen³  García Peralta, Tania² 

[1] Hospital Clinicoquirúrgico Hermanos Ameijeiras, Ciudad de La Habana, Cuba;Facultad de Ciencias Médicas Enrique Cabrera, Ciudad de La Habana, Cuba;Instituto de Hematología e Inmunología, Ciudad de La Habana, Cuba

关键词: /i> Febrile neutropenia;    risk stratification;    prognostic models;    leukemias;   

DOI  :  

学科分类：生理学与病理学

来源: SciELO

【 摘 要 】

A retrospective and analytical control cases study was carried out in 62 episodes of febrile neutropenia present in patients with malignant blood disease admitted in Hematology and Immunology Institute during 2005 and 2006. Above episodes were divided in 2 groups from its favorable course (56%) or unfavorable (44%) as well as the laboratory and clinical parameters compiled in both groups. Factors with higher association related to unfavorable course were the comorbidities presence (sepsis, dehydration, hypoxia, hypovolemia and severe mucositis), diagnosis of non-lymphoblastic, use of chemotherapy during the 7 previous days to fever onset, general status involvement, and the neutrophil absolute count lower than 100 x mm3. Patients presenting with a unfavorable course febrile neutropenia had two poor diagnosis factors. The positive predictive value of prognostic model was of 91,4% and the negative one was of 92,6% with a sensitivity and specificity of 94,1% and 89,3%, respectively.

【 授权许可】

CC BY-NC