Stimulation by Urocortin of Growth Hormone (GH) Secretion in GH-Producing Human Pituitary Adenoma Cells

Endocrine Journal

NOBORU YANAIHARA³  MASAMICHI KUROSAKI²  YOSHIO MURAKAMI¹  KUNIO KOSHIMURA¹  TOSHIAKI MORI¹  TOMOKATSU HORI²  YUZURU KATO¹ 

[1] First Division, Department of Medicine, Shimane Medical University;Division of Neurosurgery, Institute of Neurological Sciences, Tottori University School of Medicine;Yanaihara Institute

关键词: Urocortin;    GH;    Pituitary adenoma;   

DOI  :  10.1507/endocrj.44.627

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(9)Cited-By(4)Urocortin (Ucn) possesses high homology with CRH and is considered to be a ligand to type-2 CRH receptor. We investigated the effect of Ucn on hormone release from cultured GH-producing human pituitary adenoma cells in vitro. GH-producing human pituitary adenoma cells were superfused on a Sephadex G-25 column. Both Ucn (10nM) and CRH (10nM) elicited an increase in GH release from the pituitary adenoma cells in one patient with acromegaly. In contrast, GH release from the pituitary adenoma cells was stimulated by Ucn but not by CRH in the other patient with acromegaly. These preliminary findings suggest that type-2 CRH receptors are expressed in some population of GH-producing human pituitary adenoma cells and that Ucn might be involved in GH secretion from tumorous tissues in patients with acromegaly.

【 授权许可】

Unknown