Revista Cubana de Plantas Medicinales | |
Sedative effect of cycloartanol triterpene obtained from Pedilanthus tithymaloides (L.) Poit. leaves | |
Núñez Figueredo, Yanier2  Cabrera Suárez, Hiran1  | |
[1] Laboratorio Central de Farmacología, Ciudad de La Habana, Cuba;Centro de Investigación y Desarrollo de Medicamentos, Ciudad de La Habana, Cuba | |
关键词: : cycloartanol; Pedilanthus tithymaloides; sedative; triterpene; itamo real; dichlorometane extract; medicinal plants; phytopharmacology; natural products; | |
DOI : | |
学科分类:药理学 | |
来源: Editorial Ciencias Medicas | |
【 摘 要 】
INTRODUCTION: Pedilanthus tithymaloides (L.) Poit. (known as ítamo real) is a widely distributed plant in Cuba and at the same time a sustainable source of active principles. OBJECTIVE: to evaluate the neurosedative effect of cycloartanol triterpene from dichlorometane extract obtained from Pedilanthus tithymaloides (L.) Poit. leaves. METHODS: models based on exploratory behaviour, barbiturate-induced sleep, pentilenotetrazol-induced seizures and amphetamine-induced stereotyped behaviours were used. Cyclocartanol was orally administered 30 minutes before every test. RESULTS: exploratory behaviour was inhibited at over 50 mg/kg dose; amphetamine-induced stereotyped behaviours were inhibited at 200 mg/kg dose; thiopental-induced sleep was potentiated at over 50 mg/kg dose, however, protection against pentilenotetrazole-induced seizures was not observed. CONCLUSIONS: the results of several tests indicate a depressing effect on the central nervous system of laboratory animal treated with Cycloartanal; however, the sedative effect does not seem to be mediated by the GABAergic system. Anti-depressive effects were not observed either.
【 授权许可】
CC BY-NC
【 预 览 】
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