Nuclear Receptors as Targets for Drug Development: The Role of Nuclear Receptors During Neural Stem Cell Proliferation and Differentiation

Journal of Pharmacological Sciences

Yoshinori Kamisaki²  Koichiro Wada²  Kazufumi Katayama³  Atsushi Nakajima¹  Tadanori Mayumi³ 

[1] The Third Department of Internal Medicine, Yokohama City University School of Medicine;Department of Pharmacology, Graduate School of Dentistry, Osaka University;Department of Biopharmaceutics, Graduate School of Pharmaceutical Science, Osaka University

关键词: neural stem cell;    nuclear receptor;    peroxisome proliferator-activated receptor (PPAR) γ;   

DOI  :  10.1254/jphs.FMJ04008X3

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(38)Cited-By(5)The fate of stem cells, such as neural stem cells and hematopoietic stem cells, depends on strictly regulated signaling events including activation of nuclear receptors, resulting in subsequent gene induction. Recently, we demonstrated that PPARγ, a ligand-activated nuclear receptor, plays an important role in regulating the proliferation and differentiation of murine neural stem cell (NSC). NSC prepared from heterozygous PPARγ-deficient mouse exhibited a slower growth rate compared with that of wild-type mouse, which was also demonstrated in PPARγ-knockdown NSC that was generated by the lentiviral-vector-mediated RNA interference approach. These studies have important implications for understanding central nervous system functions and developing a therapy for neurodegenerative disorders. In this review, recent findings on stem cell biology, especially focusing on nuclear receptors in NSCs, including our current study, will be discussed.

【 授权许可】

Unknown