Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thaiswamp buffaloes

Journal of Veterinary Medical Science

Nitwarat RUENNARONG²  Saranya POAPOLATHEP²  Chainarong SAKULTHAEW³  Kannika WONGPANIT⁴  Susumu KUMAGAI¹  Amnart POAPOLATHEP²  Mario GIORGI⁵ 

[1] Research Center for Food Safety, Graduated School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113�?8657, Japan;Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand;Faculty of Veterinary Technology, Kasetsart University, Bangkok 10900, Thailand;Faculty of Natural Resources and Agro-industry, Chalermphrakiat Sakon Nakhon Province Campus, Kasetsart University, Sakon Nakhon 47000, Thailand;Department of Veterinary Sciences, University of Pisa, Via Livornese (lato monte), San Piero a Grado, Italy

关键词: ciprofloxacin;    enrofloxacin;    pharmacokinetic;    Thai swamp buffalo;   

DOI  :  10.1292/jvms.15-0464

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(40)Given the limited information available in this species, the aim of this study was toinvestigate the pharmacokinetic characteristics of enrofloxacin (ER) and its majormetabolite ciprofloxacin (CP) in buffaloes, Bubalus bubalis. ER wasadministered intravenously (i.v.) or subcutaneously (s.c.) to buffaloes at doses of 5.0and 7.5 mg/kg BW, and plasma, urine and fecal samples were collected until 48 hrpost-administration. The concentrations of ER and CP in the plasma, urine and feces wereanalyzed using high-performance liquid chromatography equipped with a fluorescencedetector. The plasma concentrations of ER and CP could be determined up to 24 hr and32 hr after i.v. and s.c. administrations at doses of 5.0 and 7.5 mg/kg BW,respectively. CP concentrations were always lower than those of parental drug. The s.c.bioavailability of ER was 52.36 ± 4.24% and 72.12 ± 5.39% at doses of 5.0 and 7.5 mg/kgBW, respectively. Both ER and CP were detectable in urine and feces up to 24 hr. ER and CPwere mainly excreted via the urine. Based on the pharmacokinetic data and PK-PD indices,s.c. administration of ER at doses of 5.0 and 7.5 mg/kg BW might be appropriate for thetreatment of susceptible bacterial diseases in Thai swamp buffaloes.

【 授权许可】

Unknown