Journal of Veterinary Medical Science | |
Eosinophilic Proliferative Pylephlebitis in the Liver of Japanese Beef Cattle with Fascioliasis | |
Kunioki ARAKI3  Kinji SHIROTA2  Tadashi TANIMOTO4  Yuji OHTSUKI1  | |
[1] Department of Pathology II, Kochi Medical School;Research Institute of Biosciences, Azabu University;Department of Microbiology, National Institute of Public Health;Chuo Meat Inspection Center, Kochi Prefectural Government | |
关键词: cattle; eosinophils; fascioliasis; liver; pylephlebitis; | |
DOI : 10.1292/jvms.60.1073 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(23)Cited-By(3)Intrahepatic pylephlebitis was detected in 17 Japanese beef cattle. Grossly, the intrahepatic vessels in the caudate lobe and/or in the periphery of the other hepatic lobes were thickened and protruded above the lobar surface. The vessel lumina were packed with white to red, waste thread-like contents. A few immature flukes were found in the bile ducts in 3 of the 7 cases with biliary thickening. Foci of hepatic necrosis and hemorrhage were scattered around the thickened vessels in 8 cases. Histologically, the interlobular veins were thickened due to severe intimal hyperplasia with endothelial proliferation and eosinophilic accumulation and medial hypertrophy, accompanied by fibrosis and eosinophilic infiltration in the portal areas. Hepatic tissues with necrosis and hemorrhage were surrounded by eosinophils and histiocytes including a granulomatous reaction. One immature fluke was detected in one of these regions of necrosis. Immunoperoxidase staining revealed that the small fluke, Kupffer cells, and histocytes in the liver of all cases were positively stained with anti-Japanese Fasciola sp. antiserum. Enzyme-linked immunosorbent assay of the sera of 15 cases revealed that all were positive for the anti-Fasciola antibody. On the basis of these findings, the present cases were regarded as an atypical form of fascioliasis, characterized by eosinophilic proliferative pylephlebitis of the liver.
【 授权许可】
Unknown
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