Experimental Chronic Wasting Disease in Wild Type VM Mice

Journal of Veterinary Medical Science

Hyun-Joo SOHN²  Dong-Seob TARK²  Aru BALACHANDRAN¹  Yoon-Hee LEE²  Min-Jeong KIM²  Eun-Im YUN²  Kyung-Je PARK²  Won-Yong LEE²  In-Soo CHO²  Hyo-Jin KIM²  Young-Pyo CHOI² 

[1] National and OIE Reference Laboratory for Scrapie and CWD, Ottawa Laboratory Fallowfield, Ottawa, Canadian Food Inspection Agency, Ottawa, Ontario, Canada;OIE Reference Laboratory for CWD, Animal, Plant and Fisheries Quarantine and Inspection Agency, Ministry for Food, Agriculture, Forestry and Fisheries, Anyang 430–757, Republic of Korea

关键词: CWD;    experimental transmission;    Republic of Korea;    wild type VM mice;   

DOI  :  10.1292/jvms.13-0018

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Cited-By(1)Chronic wasting disease (CWD) is a naturally occurring prion disease in North American deer (Odocoileus species), Rocky mountain elk (Cervus elaphus nelsoni) and moose (Alces alces). The disease was first confirmed in the Republic of Korea in 2001, and subsequent cases were diagnosed in 2004, 2005 and 2010. The experimental host range of CWD includes ferrets, several species of voles, white-footed mice, deer mice and Syrian golden hamsters. In addition, CWD was transmitted to the transgenic mouse over-expressing elk or deer prion protein efficiently, but not to wild type mouse. Here, we report the experimental transmission of elk CWD to conventional VM/Dk mice reaching 100% attack rate after second passage. The CWD-prion-affected wild type mice will be a useful model for future CWD studies.

【 授权许可】

Unknown