Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice

Journal of Pharmacological Sciences

Yu-jin Hwang²  Heh-In Im²  Wan Seok Joo¹  Eun-sun Lee²  Eunjoo Nam²  Yong Sik Kim² 

[1] Division of Biologics Evaluation, Korea Food and Drug Administration;Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University

关键词: 6-hydroxydopamine;    baicalein;    tyrosine hydroxylase;   

DOI  :  10.1254/jphs.SC0050014

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(18)The effects of baicalein on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity were evaluated. Intracerebroventricularly (i.c.v.) injection of 6-OHDA was done to young mice. Baicalein was administered intraperitoneally 30 min before and 90 min after i.c.v. injection. Animals received further injection of bacalein daily for 3 consecutive days. Rotarod performance was assessed, tyrosine hydroxylase (TH) Western blotting was performed, and dopamine (DA) levels and peroxidation were determined. High dose of baicalein effectively improved rotarod performance and prevented the reduction of striatal DA levels and TH contents in the striatum and subtantia nigra (SN). In addition, lipid peroxidation level was decreased by baicalein at 3 and 7 days after 6-OHDA injection. These results showed that baicalein effectively prevents the 6-OHDA-induced dopaminergic dysfunction through an antioxidative action.

【 授权许可】

Unknown