Neu2000 Potentiates a Kainate Response in Mouse Cortical Neurons

Journal of Pharmacological Sciences

Jun-mo Chung¹  Jihyun Noh¹ 

[1] Department of Brain and Cognitive Sciences, Ewha Womans University, Korea

关键词: kainic acid;    voltage-clamp;    noise analysis;   

DOI  :  10.1254/jphs.13023SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Neu2000, acting as an antioxidant with N-methyl-d-aspartate–receptor antagonism, demonstrates excellent protection against ischemic insults in rodents. In this study, we report that Neu2000 also dramatically enhances the activity of kainate (KA) receptors. Neu2000 non-competitively and reversibly potentiated KA-evoked responses in a voltage-independent manner, mainly by increasing the open probability of KA receptor channels.

【 授权许可】

Unknown