Historic, Demographic, and Genetic Evidence for Increased Population Frequencies of CCR5Δ32 Mutation in Croatian Island Isolates after Lethal 15th Century Epidemics

Croatian Medical Journal

Zgaga, Lina¹  Rudan, Igor⁴  Campbell, Harry²  Rudan, Diana⁵  Grković, Ivica³  Kolčić, Ivana¹  Boraska, Vesna⁸  Polašek, Ozren¹  Torlak, Vesela³  Vitart, Veronique⁶  Mulić, Rosanda³  Wright, Alan F.⁶  Barbalić, Maja²  Zemunik, Tatijana⁸  Ropac, Darko³  Biloglav, Zrinka¹  Ristić, Smiljana⁷  Smoljanović, Mladen⁸  Hayward, Caroline⁶ 

[1] Andrija Štampar School of Public Health, School of Medicine, University of Zagreb, Croatia;Institute of Anthropological Research, Zagreb, Croatia;University of Split Hospital Center, Split, Croatia;Croatian Centre for Global Health, School of Medicine, University of Split, Croatia;''Dubrava'' University Hospital, Zagreb, Croatia;Human Genetics Unit, Western General Hospital, Edinburg, UK;School of Medicine, University of Rijeka, Croatia;School of Medicine, University of Split, Croatia

关键词: demography;    population genetics;    CCR5Δ32;    selection;    epidemic;    isolated populations;    Croatia;   

DOI  :  

学科分类：卫生学

来源: Medicinska Naklada Co.

【 摘 要 】

Aim To assess the frequency of 32 base pair deletion in CCR5 (CCR5Δ32), which has been shown to confer resistance to HIV infection in a homozygous form, in 10 isolated island communities of Dalmatia, Croatia, with different histories of...

【 授权许可】

Unknown