Infection of the lymphatic system by Aureobasidium pullulans in a patient with erythema nodosum leprosum

Brazilian Journal of Infectious Diseases

Gomes, Ciro Martins²  Reis, Carmélia Matos Santiago¹  Coutinho, Anglya Samara Silva Leite²  Teixeira, Marcus de Melo¹  Morais, Orlando Oliveira de²  Porto, Cláudia¹ 

[1] UnB, Brasília, Brazil;Universidade de Brasília, Brasília, Brazil

关键词: HIV;    pneumonia;    macrolides;    mortality.;   

DOI  :  10.1590/S1413-86702011000300019

来源: Contexto

【 摘 要 】

Aureobasidium pullulans is a causal agent of phaeohyphomycosis, occasionally found in men and animals. As an agent of different opportunistic fungal processes, it may cause fungemia, systemic infections and abscesses in different viscera. This paper aims to report a case of a patient with infection of the lymphatic system by A. pullulans. A 23-year-old patient being treated for erythema nodosum leprosum presented a 60-day complaint of daily fever, hoarseness, odynophagia and weight loss. Laboratory tests showed pancytopenia with severe neutropenia, cervical adenomegaly and solid contrast uptake lesion in the oropharyngeal region. Due to neutropenia and sepsis the patient was initially treated with cefepime and vancomycin, but there was no clinical improvement. Lymph node puncture-aspiration showed yeast-form fungus identified as A. pullulans by sequencing ITS region. The patient was treated with amphotericin B deoxycholate, leading to complete recovery of bone marrow function and regression of adenomegaly and the oropharyngeal lesion.

【 授权许可】

CC BY-NC-ND