Epidemiological, clinical, hematological, and pathological aspects of acute erythroid leukemia (LMA M6) in cats

Pesquisa Veterinária Brasileira

Fighera, Rafael A.¹  Barros, Claudio S.L.¹  Souza, Tatiana M.¹  Tochetto, Camila² 

[1] UFSM, Santa Maria;Universidade Federal de Santa Maria (UFSM), Santa Maria, Brasil

关键词: Diseases of cats;    hematology;    hematopathology;    acute erythroid leukemia;    erythroleukemia;    erythremic myelosis.;   

DOI  :  10.1590/S0100-736X2011000700011

来源: Colegio Brasileiro de Patologia Animal-CBPA

【 摘 要 】

The epidemiological, clinical, hematological, and pathological aspects of acute erythroid leukemia (LMA M6) were studied in 10 cats that died from this condition. The results obtained in the present study differ from those previously described in the literature regarding the following aspects: 1) The disease occurred as a bimodal model related to the age of affected cats, in which 50% were1-3-years-old and 50% were 10 years-old or above; 2) almost all affected cats (87.5%) displayed polychromasia, possible resulting from extramedullar erythropoiesis; 3) in all cases there were multiple foci of hematopoietic cells, mainly erythropoietic, in multiple organs including spleen (85.7%), lymph nodes (71.4%), liver (57.1%), and kidney (28.6%); 4) in some cases (28.6%) these foci could be observed on gross examination as metastasis, but they always histologically differ from bone marrow in regard to the proportion of erythroid precursors involved; 5) at least in one case a continuum patologicum occurred with the condition evolving to another form of LMA (LMA M4), a phenomenon coined as "lineage infidelity". This paper discuss these differences and stresses the fundamental criteria to establish a definitive diagnosis of this condition, which is the most import form of leukemia in cats from our region. Index terms: Diseases of cats, hematology, hematopathology, acute erythroid leukemia, erythroleukemia, erythremic myelosis.   INTRODUÇÃOLeucemia eritroide aguda é uma forma de apresentação de neoplasia do sistema hematopoético em que há envolvimento de células imaturas do compartimento eritroide (Valli et al. 2002). Segundo o Grupo de Estudos Franco-Americano-Britânico (Grupo FAB) (Bennett et al. 1976) e a Organização Mundial de Saúde (OMS) (Jaffe et al. 2001), que se baseia no Clinical Advisory Committee Meeting, ocorrido em Airlie House, Virginia, em Novembro de 1997 (Harris et al. 2000), leucemia eritroide aguda é classificada como uma forma de leucemia mieloide aguda (LMA M6) e subdividida em duas formas de apresentação clinicopatológicas: LMA M6A, mais frequentemente descrita em humanos (Valli 2007a), e LMA M6B, muito mais comumente relatada em animais, principalmente em camundongos (Ney & D'Andrea 2000, Moreau-Gachelin 2006) e gatos (Jain et al. 1991, Valli 2007a,b), e raramente em cães (Anderson & Johnson 1962, Groulade & Guillon 1967, Liu & Carb 1968, Tolle et al. 1977), bovinos (Watanabe et al. 1998), chimpanzés (McClure et al. 1974) e ratos (Groulade & Guillon 1967, Bird & Huggins 1971). A primeira, também denominada de eritroleucemia, consiste em um neoplasma bilinhagem, que envolve mieloblastos e eritroblastos (Bennett et al. 1976, Jain et al. 1991, Harris et al. 2000). A segunda, também chamada mielose eritrêmica (Bennett et al. 1976, Valli 2007a,b), leucemia eritroide pura (Harris et al. 2000, Jaffe et al. 2001), eritroleucemia com predominância eritroide (Jaffe et al. 2001), LMA M6Er (Jain et al. 1991) e eritremia aguda (Jarret & Mac

【 授权许可】

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