Establishment and Characterization of a Feline Large Granular Lymphoma Cell Line Expressing Interleukin 2 Receptor α-Chain

Journal of Veterinary Medical Science

Atsuhiko HASEGAWA¹  Hajime TSUJIMOTO¹  Toshihiro WATARI¹  Yasuyuki MOMOI¹  Kouichi OHNO¹  Naoko HAYASHI¹  Yasunobu MATSUMOTO¹  Yukari OKAMOTO¹  Ryo GOITSUKA¹ 

关键词: feline;    interleukin 2;    large granular lymphocyte;   

DOI  :  10.1292/jvms.55.863

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(9)Cited-By(1)A feline large granular lymphocyte (LGL) cell line was established from a cat with an alimentary-form lymphoma. This cell line, designated as FGL, had many large azurophilic granules in the cytoplasm, which were typical to LGL cells. Proviral genome of feline leukemia virus was detected in the chromosomal DNA of FGL cells, and reverse transcriptase activity was also demonstrated in the culture supernatant. Furthermore, we found expression of interleukin 2 (IL-2) receptor α-chain on the cell surface of FGL and its natural killer activity against human erythroblastic leukemia cell line, K562.

【 授权许可】

Unknown