Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex

Journal of Pharmacological Sciences

Katsunori Iwasaki²  Kotaro Takasaki²  Michihiro Fujiwara²  Ai Nogami²  Nobuaki Egashira²  Kenichi Mishima²  Ryozo Oishi¹  Ryoji Nishimura³  Ayumi Ishibashi²  Naoki Uchida³ 

[1] Department of Pharmacy, Kyushu University Hospital, Japan;Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan;Department of Psychiatry, Fukuoka University School of Medicine, Japan

关键词: sleep;    social isolation;    Yokukansan;   

DOI  :  10.1254/jphs.11079SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(11)In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sleep in group-housed mice. The prolongation of sleeping time by YKS was reversed by bicuculline (3 mg/kg, i.p.) and flumazenil (3 mg/kg, i.p.), but not WAY100635. These findings suggest that the GABAA – benzodiazepine receptor complex, but not 5-HT1A receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation.

【 授权许可】

Unknown