Plasma kisspeptin levels in male cases with hypogonadism

Endocrine Journal

Masato Kotani³  Tsuyoshi Hirai⁴  Fumihiko Katagiri¹  Jiro Kagawa² 

[1] Laboratory of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan;Department of Pediatrics, Fujieda Municipal General Hospital, Fujieda 426-8677, Japan;Asahina Shinryoujo, Shizuoka 421-1115, Japan;Department of Gynecology and Obstetrics, Fujieda Municipal General Hospital, Fujieda 426-8677, Japan

关键词: Kisspeptin;    Metastin;    Gonadotropin;    Hypogonadism;    Azoospermia;   

DOI  :  10.1507/endocrj.EJ14-0137

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(14)Cited-By(2)The hypothalamic hormone kisspeptin (metastin) regulates human reproduction by modulating gonadotropin-releasing hormone (GnRH) secretion.Kisspeptin is detected in peripheral blood, although GnRH is not.In this study, we measured plasma kisspeptin levels in four male cases with hypogonadism and seven normal male controls using enzyme immunoassay (EIA) to elucidate the clinical implications of kisspeptin levels in male hypogonadism.The results showed a variety of plasma kisspeptin levels: 6.0 fmol/mL in a male with isolated hypogonadotropic hypogonadism (IHH), 43.2 fmol/mL in a male with Kallmann’s syndrome, 40.7 fmol/mL in a male with azoospermia, 323.2 fmol/mL in a male with hypergonadotropic hypogonadism, and 12.3 ± 2.5 fmol/mL (mean ± SD) in seven normal controls.Except for the case with IHH, the plasma kisspetin levels were elevated in the three cases with Kallmann’s syndrome, azoospermia, and hypergonadotropic hypogonadism.The reason why the three cases had high values was their lesions were downstream of the kisspeptin neuron in the hypothalamic-pituitary-gonadal axis, suggesting that elevated kisspeptin levels were implicated in hypothalamic kisspeptin secretion under decreased negative feedback of gonadal steroids.The result that the plasma kisspeptin levels were decreased by gonadotropin therapy in the case with Kallmann’s syndrome supported this hypothesis.In conclusion, to measure plasma kisspeptin levels could be useful for better understanding of male hypogonadism.

【 授权许可】

Unknown