A Suspected Case of Ornithine Transcarbamylase Deficiency in a Cat

Journal of Veterinary Medical Science

Takashi SUZUKI¹  Makoto WASHIZU⁴  Masaki SAWAMURA¹  Chunhua ZHANG³  Tsukimi WASHIZU²  Isamu MATSUMOTO³ 

[1] Suzuki Animal Hospital;Department of Clinical Pathology, Nippon Veterinary and Animal Science University;MILS;Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University

关键词: feline;    ornithine transcarbamylase;    urea cycle;   

DOI  :  10.1292/jvms.66.701

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(8)Cited-By(2)An 18 month-old, intact female American Shorthair cat was presented for evaluation of stunted growth and postprandial depression. Fasting serum ammonia and serum bile acid concentrations were above reference ranges at 396 μg/dl and 6.5 μmol/ l and their postprandial concentrations were 785 μg/dl and 9.5 μmol/l, respectively. The initial tentative diagnosis of a portosystemic shunt was excluded by mesenteric portography and histopathology of the liver. The cat was then suspected of a urea cycle enzyme deficiency and its urine was analyzed by gas chromatography-mass spectrometry. A presumptive diagnosis of ornithine transcarbamylase deficiency was made on the basis of the detection of orotic acid and uracil.

【 授权许可】

Unknown