Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D1-Like Receptors in Mice

Journal of Pharmacological Sciences

Ji Hoon Jeong²  Choon-Gon Jang⁴  Hyun Ji Kim¹  Eun-Joo Shin¹  Hyoung-Chun Kim¹  Kiyofumi Yamada³  Toshitaka Nabeshima³ 

[1] Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Korea;Department of Pharmacology, College of Medicine, Chung Ang University, Korea;Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan;Department of Pharmacology, College of Pharmacy, Sungkyunkwan University, Korea

关键词: extremely low frequency magnetic field;    locomotor activity;    dopaminergic receptor;   

DOI  :  10.1254/jphs.SC0070348

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(11)We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF–induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D1-like receptor antagonist, but not with sulpiride, a dopaminergic D2-like receptor antagonist, inhibited ELF-MF–induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF–induced behavioral responses are, at least in part, mediated by activation of dopamine D1-like receptors.

【 授权许可】

Unknown