Quercetin Prevents Cardiac Hypertrophy Induced by Pressure Overload in Rats

Journal of Veterinary Medical Science

Hee-Yul AHN²  Jang-Soo HONG⁴  Jing-Jun HAN¹  Jia HAO²  Chan-Hyung KIM²  Yong-Soon LEE³ 

[1]Department of Thoracic and Cardio vascular Surgery, Guang Dong Medical College FuTian Hospital

[2]Department of Pharmacology, College of Medicine, Chungbuk National University

[3]Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University

[4]Department of Thoracic and Cardiovascular Surgery, College of Medicine, Chungbuk National University

关键词: cardiac hypertrophy;    pressure overload;    quercetin;   

DOI  :  10.1292/jvms.71.737

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(21)Cited-By(16)Inhibition of cardiac hypertrophy leads to a significant reduction in cardiovascular mortality and morbidity. Quercetin is by far the most abundant flavonoid and believed to ameliorate cardiovascular disease. Therefore, we investigated whether quercetin supplementation could attenuate the development of cardiac hypertrophy induced by pressure overload. Three weeks after suprarenal transverse abdominal aortic constriction, heart to body weight (HW/BW) ratio increased compared to the sham group (3.40 ± 0.06 mg/g versus 2.83 ± 0.02 mg/g, P<0.001). The quercetin administered group showed complete inhibition of cardiac hypertrophy (2.85 ± 0.01 mg/g, P<0.001). Malonyldialdehyde production induced by pressure overload was suppressed by quercetin. The activities of extracellular signal-regulated kinase (ERK1/2), p38 MAP kinase, Akt and GSK-3β were significantly increased with pressure overload and attenuated by quercetin treatment. We conclude that quercetin appears to block the development of cardiac hypertrophy induced by pressure overload in rats and that these effects may be mediated through reduced oxidant status and inhibition of ERK1/2, p38 MAP kinase, Akt and GSK-3β activities.

【 授权许可】

Unknown