Present status of sulfonylurea treatment for type 2 diabetes in Japan: Second report of a cross-sectional survey of 15,652 patients

Endocrine Journal

Keiko Arai²  Koich Hirao²  Ikuro Matsuba²  Kiyokazu Matoba²  Hisao Mori²  Akira Kanamori²  Masahiko Takai²  Yasuo Terauchi¹  Hiroshi Takeda²  Mikio Yamauchi³ 

[1] Department of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine, Yokohama, Japan;The Japanese Medical and Dental Practitioners for the Improvement of Medical Care, Tokyo, Japan;Health Education Center Science Clinic, Yokohama, Japan

关键词: Sulfonylurea;    T2DM;    Cross-sectional survey;    HbA1c;    General practitioner;   

DOI  :  10.1507/endocrj.K09E-366

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(29)Cited-By(21)Sulfonylureas are commonly used for the treatment of patients with type 2 diabetes mellitus (T2DM). However, some clinical concerns regarding their use have grown over the past decade. Thus, results of a previous Japan-wide cross-sectional survey of patients with type 2 diabetes mellitus (T2DM) were analyzed to determine the present status and problems associated with the use of sulfonylureas in the treatment of T2DM by general practitioners (GPs) and diabetes specialists. Of 15,652 patients across 721 clinics and hospitals from the previous survey, 15,350 were diagnosed as T2DM (14,312 by GPs and 1,038 by specialists). For each patient, data were collected for HbA1c levels, age, height, body weight, and treatment modality. Of T2DM patients being treated by GPs, 35.4% and 60.0% received sulfonylureas in entire oral drugs or as monotherapy, respectively, compared with 29.2% and 61.2% of patients, respectively, treated by specialists. Of the patients treated with sulfonylurea monotherapy, 1335 patients (35.2%) achieved HbA1c <6.5%, whereas HbA1c was ?8.0% in 531 patients (14.0%). Patients with HbA1c levels ?8.0% had a higher body mass index, used glibenclamide more frequently, and used higher doses of sulfonylureas than patients in whom HbA1c levels were <6.5%. In conclusion, the present study shows that sulfonylureas are central in the treatment of T2DM in Japan. However, careful consideration of suitable patients, agents, and doses is necessary to achieve appropriate glycemic control.

【 授权许可】

Unknown