Plasma Homocysteine Levels in Hyperthyroid Patients

Endocrine Journal

Yalçin ARAL¹  Gönül KOǹ  Rüstü SERTER¹  Berrin DEMIRBAS¹  Erman ÇAKAL¹  Cavit ÇULHA¹  Mesut ÖZKAYA¹  Nese GÜLÇELIK¹ 

[1] Department of Endocrinology and Metabolism, Ankara Research and Training Hospital

关键词: Homocysteine;    Folate;    Hyperthyroidism;   

DOI  :  10.1507/endocrj.51.121

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(19)Cited-By(4)Hyperhomocysteinemia is a risk factor for premature atherosclerotic vascular diseases. It is known that plasma homocysteine levels are higher in hypothyroid patients compared to healthy subjects. The aim of our study was to assess plasma total homocysteine concentrations in hyperthyroid patients before and after treatment when euthyroid status was reached and compare them with control group. Thirteen hyperthyroid patients (age, 42.9 ± 15.6 year) and eleven healthy subjects (age, 39.9 ± 12.5 year) were involved in the study. Plasma levels of homocysteine and serum cholesterol, triglyceride, HDL cholesterol, urea, creatinine, vitamin B12, folate were measured before and after treatment. LDL cholesterol and creatinine clearences were calculated. Pretreatment homocycteine levels of the hyperthyroid patients were significantly lower than healthy controls (11.5 ± 3.6 μmol/L vs. 15.1 ± 4.5 μmol/L, respectively, p<0.05). Posttreatment homocysteine levels were significantly higher than pretreatment levels (13.9 ± 6.3 μmol/L vs. 11.5 ± 3.6 μmol/L, respectively, p<0.05) and posttreatment creatinine clearance were lower than pretreatment level (103.5 ± 12.7 ml/min vs. 114.2 ± 9.3 ml/min, respectively, p<0.01). Lower homocysteine levels in hyperthyroidism can be partially explained with the changes in creatinine clearance.

【 授权许可】

Unknown