The Antipsychotic and Antiemetic Drug Prochlorperazine Delays the Ventricular Repolarization of the In Situ Canine Heart

Journal of Pharmacological Sciences

Sachiko Honsho²  Kentaro Ando²  Keitaro Hashimoto²  Akira Takahara²  Atsushi Sugiyama²  Yoshioki Satoh¹  Kai Wang² 

[1] Department of Medicine, Koshu Rehabilitation Hospital;Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi

关键词: prochlorperazine;    antipsychotic drug;    monophasic action potential;    long QT syndrome;    torsades de pointes;   

DOI  :  10.1254/jphs.FPJ04038X

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(21)Cited-By(9)Electropharmacological effect of the antipsychotic and antiemetic drug prochlorperazine was assessed using the halothane-anesthetized in vivo canine model (n = 5). Up to 10 times higher than the clinically relevant doses of prochlorperazine (≤ 3 mg/kg, i.v.) did not induce cardiohemodynamic collapse in the model. Meanwhile, clinically relevant to supratherapeutic doses (0.3 – 3 mg/kg, i.v.) prolonged the ventricular repolarization period in a dose-related and reverse-use dependent manner that could become proarrhythmic substrates. Thus, caution has to be paid on the use of prochlorperazine particularly for patients with risks of the elevated plasma drug concentration, compromised cardiac repolarization, and/or frequent ventricular premature beats.

【 授权许可】

Unknown