Effect of CD4+CD25+ T Cell-Depletion on Acute Lethal Infection of Mice with Trypanosoma congolense

Journal of Veterinary Medical Science

Osamu TAGUCHI²  Boniface NAMANGALA¹  Naoaki YOKOYAMA¹  Yuzuru IKEHARA⁴  Kunio TSUJIMURA⁵  Noboru INOUE¹  Chihiro SUGIMOTO³ 

[1] National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine;Aichi Cancer Center Research Institute;Research Center for Zoonosis Control, Hokkaido University;National Institute of Advanced Industrial Science and Technology;Hamamatsu University School of Medicine

关键词: CD4+CD25+ T cell;    depletion;    Th1/Th2 cytokines;    trypanosomosis;    trypanotolerance;   

DOI  :  10.1292/jvms.70.751

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(35)Cited-By(2)Despite the immense socio-economic repercussions of African trypanosomosis (AT), there is currently no effective control measure against the disease. Characterization of mechanisms governing resistance and/or susceptibility to AT could suggest interventions that might lead to more effective disease control. The present study was designed in an attempt to address the possible role of CD4+CD25 + T cells during an acute lethal infection of mice with Trypanosoma congolense, the causative agent of AT in domestic animals, through selective depletion using anti-CD25 monoclonal antibody. Accordingly, CD4+CD25+ T-cell-depletion resulted in a significant reduction or delay in parasitemia, pathology, and mortality, as compared to controls. The apparent resistance in CD4+CD25 +-T-cell-depleted mice correlated with a profound suppression of Th2 cytokines in vitro and in vivo, culminating in a net Th1 cytokine environment. Cumulatively, these findings suggest that CD4+CD25+ T-cell- depletion improves the trypanotolerance of highly susceptible BALB/c mice acutely infected with the lethal T. congolense.

【 授权许可】

Unknown