Cruciferous vegetables and colo-rectal cancer

Proceedings of the Nutrition Society

Anthony Lynn¹  Zoë Fuller¹  Andrew Collins¹  Brian Ratcliffe¹  Kevin Hillman¹ 

关键词: Cruciferous vegetables;    Broccoli;    Colo-rectal cancer;   

DOI  :  10.1079/PNS2005486

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

Cruciferous vegetables have been studied extensively for their chemoprotective effects. Although they contain many bioactive compounds, the anti-carcinogenic actions of cruciferous vegetables are commonly attributed to their content of glucosinolates. Glucosinolates are relatively biologically inert but can be hydrolysed to a range of bioactive compounds such as isothiocyanates (ITC) and indoles by the plant-based enzyme myrosinase, or less efficiently by the colonic microflora. A number of mechanisms whereby ITC and indoles may protect against colo-rectal cancer have been identified. In experimental animals cruciferous vegetables have been shown to inhibit chemically-induced colon cancer. However, the results of recent epidemiological cohort studies have been inconsistent and this disparity may reflect a lack of sensitivity of such studies. Possible explanations for the failure of epidemiological studies to detect an effect include: assessment of cruciferous vegetable intake by methods that are subject to large measurement errors; the interaction between diet and genotype has not been considered: the effect that post-harvest treatments may have on biological effects of cruciferous vegetables has not been taken into account.

【 授权许可】

Unknown