Hepatic lesions in a redstriped rockfish (Sebastes proriger) suggestive of a herpesvirus infection

Diseases of Aquatic Organisms

M. L. Kent¹  M. S. Myers¹ 

关键词: Herpesvirus;    Rockfish;    Liver lesions;   

DOI  :  10.3354/dao041237

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: Unusual lesions were observed in a redstriped rockfish (Sebastes proriger) collected during a survey of marine fishes off the coast of British Columbia, Canada. This particular fish exhibited prominent hepatomegaly, with large,coalescing, multiple hemorrhages. The affected liver exhibited remarkable histological changes that, taken together, strongly suggested infection by a virus of the herpesvirus group. Multiple, multinucleated giant cells or syncytia of hepatocytes occurredthroughout the liver and were associated with massive, coalescing areas of coagulation necrosis, edema, congestion and cavernous hemorrhages (peliosis hepatis) with thrombosis. In addition, the liver showed multifocal inflammation, characterized byperivascular and peribiliary cuffing of mononuclear inflammatory cells. High magnification of the syncytia revealed that the nuclei were pleomorphic, hyperchromatic, and typically contained eosinophilic to densely amphophilic inclusion bodies of varyingsize, closely resembling Cowdry Type A inclusions. These inclusions stained red to purple in Feulgen¹s stain, indicating presence of DNA. Electron-lucent spheres (~100 nm diameter) were observed within hepatocyte nuclei by transmission electronmicroscopy, suggestive of herpesvirus capsids. To our knowledge, this is the first report of a putative or confirmed herpesvirus infection in any rockfish of the genus Sebastes.

【 授权许可】

Unknown