Evaluation of cellular proliferation as prognostic indicator for canine cutaneous mast cell tumors

Pesquisa Veterinária Brasileira

Kleeb, Silvia Regina¹  Strefezzi, Ricardo De F.²  Dias, José Luiz Catão³  Xavier, José Guilherme¹ 

[1] Universidade Metodista de São Paulo, São Bernardo do Campo, Brasil;Universidade de São Paulo, Pirassununga, Brazil;Universidade de São Paulo, São Paulo

关键词: Mast cell tumor;    PCNA;    Ki67;    proliferation markers;    prognostic markers.;   

DOI  :  10.1590/S0100-736X2010000700009

来源: Colegio Brasileiro de Patologia Animal-CBPA

【 摘 要 】

This study evaluated the prognostic value of cell proliferation markers for canine cutaneous mast cell tumor cases. Twenty-three cases were analyzed with regard to immuno-histochemical expression of Ki67 and Proliferating Cell Nuclear Antigen (PCNA), and were clinically followed up. Ki67 expression was related to the traditional histopathological grading (p= 0.0418; p<0.05 between grades I and III), and was a reliable indicator of post-surgical survival (p=0.0089). PCNA immunoexpression did not show statistically significant values in the prediction of disease-related mortality and survival, although it is correlated to Ki67 expression. These results confirm that information about tumoral proliferative activity through Ki67 immunohistochemical detection can improve canine cutaneous mast cell tumor grading with regard to malignancy.Index

【 授权许可】

CC BY-NC