Combined Effects of Treatment with Trientine, a Copper-Chelating Agent, and X-Irradiation on Tumor Growth in Transplantation Model of a Murine Fibrosarcoma

Journal of Veterinary Medical Science

Noboru HORIGUCHI²  Daiji ENDOH²  Toyo OKUI¹  Ryou HIRAI²  Masanobu HAYASHI²  Yuusuke ISHIHARA² 

[1] Hokkaido Institute of Public Health;Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University

关键词: fibrosarcoma;    transplantation model;    trientine;    tumor growth;    X-irradiation;   

DOI  :  10.1292/jvms.69.1039

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(49)Cited-By(1)Combined effects of treatment with trientine, a copper-chelating agent, and X-irradiation on development of fibrosarcoma using a murine transplantation model in vivo and on cellular survival in vitro were examined. Copper contents in the tumors and serum of trientine-treated mice were significantly lower than those of untreated mice. The tumor volumes of mouse fibrosarcoma QRsp-11 cells increased more slowly in the trientine-treated and the X-irradiated mice than in the control mice from 10 to 24 days postinoculation. The extent of inhibition of tumor growth by X-irradiation at 3 Gy was similar to that obtained by treatment with trientine. A combination of trientine and X-irradiation at 3 Gy showed inhibitory effects on tumor growth similar to those obtained by X-irradiation at 6 Gy. The results showed that trientine and X-irradiation interacted additively in inhibition of tumor growth. When QRsp-11 cells and mouse and bovine endothelial cells were treated with trientine after X-irradiation, the surviving fractions of the cells with combined treatments were essentially consistent with the products of the surviving fractions of trientine-treated cells and those of X-irradiated cells. When the cells were pretreated with trientine and X-irradiated, the surviving fractions of the pretreated cells were lower than those of cells without treatment.

【 授权许可】

Unknown