Progression of Glomerulonephritis to End-Stage Kidney Disease in a Cat with Nephrotic Syndrome

Journal of Veterinary Medical Science

Atsuko HAISHIMA⁴  Ryosuke KOBAYASHI⁴  Tamio OHMURO¹  Kaoru INOUE⁴  Kyohei YASUNO⁴  Kikumi OGIHARA³  Junichi KAMIIE²  Kinji SHIROTA²  Naoyuki AIHARA²  Mihoko ONO⁴ 

[1] Ohmuro Veterinary Clinic;Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University;Laboratory of Environmental Pathology, Azabu University;Reseach Institute of Biosciences, Azabu University

关键词: chronic renal failure;    feline;    glomerulonephritis;    nephrotic syndrome;    renal biopsy;   

DOI  :  10.1292/jvms.10-0227

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(12)A percutaneous renal biopsy was performed on a 3-year-old female Japanese domestic cat with pleural effusion, mild azotemia, hypoalbuminemia, hypercholesterolemia, and proteinuria. Glomerular lesions included mild diffuse hypercellularity and numerous capsular adhesions with segmental sclerosis/hyalinosis of glomerular tufts. Electron microscopy revealed many subendothelial dense deposits with characteristic outer protrusion of glomerular basement membrane. Diffuse and global granular deposits of IgG and C3 were detected along the capillary walls. Tubulo-interstitial changes were mild at the time of biopsy, but progression of the disease was predicted because of the many capsular adhesions of the glomerular tufts. The cat was fed a prescription diet without any other specific or symptomatic therapy after renal biopsy, and died 43 weeks after the biopsy. At necropsy, extensive tubulo-interstitial fibrosis and mononuclear cell infiltration had developed throughout the cortex and outer medulla, and most glomeruli had extensive global sclerosis or obsolescence with less prominent depositions of IgG and C3.

【 授权许可】

Unknown