期刊论文详细信息
Endocrine Journal
The evolution of non-diabetic hyperglycemia: a longitudinal study
Yasushi Fumisawa4  Toru Aizawa3  Kenshi Hayashi5  Rie Oka2  Keishi Yamauchi3  Masa-aki Kawashiri5  Masakazu Yamagishi5  Masayuki Yamada1  Kunimasa Yagi5 
[1] Data Science, Clinical Research Department, Kissei Pharmaceutical, Tokyo, Japan;Department of Internal Medicine, Hokuriku Central Hospital, Toyama, Japan;Diabetes Center, Aizawa Hospital, Matsumoto, Japan;Rehabilitation Center, Aizawa Hospital, Matsumoto, Japan;Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
关键词: Normal glucose tolerance;    Impaired fasting glucose;    Impaired glucose tolerance;    OGTT;   
DOI  :  10.1507/endocrj.EJ13-0359
学科分类:内分泌与代谢学
来源: Japan Endocrine Society
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【 摘 要 】

References(34)Cited-By(3)The risk factors for impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) have yet to be established.Our aim was to elucidate the predisposing factors for IFG and IGT in Japanese subjects with normal glucose tolerance (NGT).Using a 75 g oral glucose tolerance test (OGTT), we analyzed 604 adults with the ADA-defined NGT.Follow-up glucose tolerance status was determined by 75 g OGTT performed 3.7 yrs later.Glucose-stimulated insulin secretion (GSIS), whole body insulin sensitivity (SI) and beta cell function (BCF) were estimated by Stumvoll indices, ISIMatsuda, and a product of Stumvoll 1st and ISIMatsuda, respectively, and hepatic SI by quantitative insulin sensitivity check index.Logistic regression analysis revealed that attenuated BCF due to low GSIS was an independent risk factor for IFG.Low whole body SI was an additional risk for IGT.Male gender and high BMI were independently related to the progression to both IFG and IGT, whereas a positive diabetes family history was independently related to IGT.The worsening of glucose tolerance at large was predicted with 66% sensitivity by risk engine with GSIS, whole body SI, gender, BMI and glucose.This finding may help when implementing early intervention strategies for diabetes.

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