The evolution of non-diabetic hyperglycemia: a longitudinal study

Endocrine Journal

Yasushi Fumisawa⁴  Toru Aizawa³  Kenshi Hayashi⁵  Rie Oka²  Keishi Yamauchi³  Masa-aki Kawashiri⁵  Masakazu Yamagishi⁵  Masayuki Yamada¹  Kunimasa Yagi⁵ 

[1] Data Science, Clinical Research Department, Kissei Pharmaceutical, Tokyo, Japan;Department of Internal Medicine, Hokuriku Central Hospital, Toyama, Japan;Diabetes Center, Aizawa Hospital, Matsumoto, Japan;Rehabilitation Center, Aizawa Hospital, Matsumoto, Japan;Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan

关键词: Normal glucose tolerance;    Impaired fasting glucose;    Impaired glucose tolerance;    OGTT;   

DOI  :  10.1507/endocrj.EJ13-0359

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(34)Cited-By(3)The risk factors for impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) have yet to be established.Our aim was to elucidate the predisposing factors for IFG and IGT in Japanese subjects with normal glucose tolerance (NGT).Using a 75 g oral glucose tolerance test (OGTT), we analyzed 604 adults with the ADA-defined NGT.Follow-up glucose tolerance status was determined by 75 g OGTT performed 3.7 yrs later.Glucose-stimulated insulin secretion (GSIS), whole body insulin sensitivity (SI) and beta cell function (BCF) were estimated by Stumvoll indices, ISIMatsuda, and a product of Stumvoll 1st and ISIMatsuda, respectively, and hepatic SI by quantitative insulin sensitivity check index.Logistic regression analysis revealed that attenuated BCF due to low GSIS was an independent risk factor for IFG.Low whole body SI was an additional risk for IGT.Male gender and high BMI were independently related to the progression to both IFG and IGT, whereas a positive diabetes family history was independently related to IGT.The worsening of glucose tolerance at large was predicted with 66% sensitivity by risk engine with GSIS, whole body SI, gender, BMI and glucose.This finding may help when implementing early intervention strategies for diabetes.

【 授权许可】

Unknown