Quantitative Acylation of Amino Compounds Catalysed by Penicillin G Acylase in Organic Solvent at Controlled Water Activity

Croatica Chemica Acta

Basso, Alessandra¹  De Martin, Luigi¹  Biffi, Stefania¹  Linda, Paolo¹  Gardossi, Lucia¹ 

[1] Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Trieste, Piazzale Europa 1, 34127 Trieste, Italy

关键词: penicillin G acylase;    kinetically controlled synthesis;    organic solvent;    acylation;    water activity;    derivatised L-amino acids;   

DOI  :  

学科分类：化学（综合）

来源: Croatica Chemica Acta

【 摘 要 】

Covalently immobilised penicillin G acylase (PGA-450) accepts in toluene, at controlled water activity (a w ), a broad range of amino compounds as nucleophiles in kinetically controlled acylation. Hydrolytic reactions were prevented and...

【 授权许可】

Unknown